Bioinspired Hydrogels to Engineer Cancer Microenvironments

Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments.

Engineering cellular microenvironments involves biochemical factors, the extracellular matrix (ECM) and the interaction with neighbouring cells. This progress report provides a critical overview of key studies that incorporate growth factor (GF) signalling and mechanotransduction into the design of advanced microenvironments. Materials systems have been developed for surface-bound presentation ...

Protein-patterned hydrogels: Customized cell microenvironments.

Controlling Osteogenic Stem Cell Differentiation via Soft Bioinspired Hydrogels

Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant attention as a physical osteoinductive signal that can contribute to endochondral ossification of a cartilaginous skeletal template. However, MSCs also participate in intramembranous bone formatio...

Designing degradable hydrogels for orthogonal control of cell microenvironments

Degradable and cell-compatible hydrogels can be designed to mimic the physical and biochemical characteristics of native extracellular matrices and provide tunability of degradation rates and related properties under physiological conditions. Hence, such hydrogels are finding widespread application in many bioengineering fields, including controlled bioactive molecule delivery, cell encapsulati...

Nuclear Microenvironments in Cancer Series PROSPECTS Nuclear Microenvironments in Cancer Diagnosis and Treatment

The nuclear architecture plays an important role in the temporal and spatial control of complex functional processes within the nucleus. Alterations in nuclear structures are characteristic of cancer cells and the mechanisms underlying these perturbations may directly contribute to tumor development and progression. In this review, we will highlight aspects of the nuclear microenvironment that ...